These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of cocaine on rat brain enzymes.
    Author: Pradhan S.
    Journal: Arch Int Pharmacodyn Ther; 1983 Dec; 266(2):221-8. PubMed ID: 6141775.
    Abstract:
    Acute administration of cocaine (20 mg/kg, i.p.) stimulated activity of striatal tyrosine hydroxylase (TH) which reached its maximum level at 10 min and returned to normal between 20-40 min. However, tryptophan hydroxylase (TPH) activity in the pons-medulla was reduced to a minimum at 10 min after its injection and returned to normal between 20-40 min. Activity of monoamine oxidase (MAO) was significantly reduced at 10 min and increased MAO (Type A) at 20 min showing a biphasic effect of cocaine on this enzyme. Relation of the time-courses of cocaine effects on the activity of these enzymes and the levels of related neurotransmitters is discussed.
    [Abstract] [Full Text] [Related] [New Search]