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  • Title: Hepatic metallothionein production and resistance to heavy metals by rainbow trout (Salmo gairdneri)--II. Held in a series of contaminated lakes.
    Author: Roch M, McCarter JA.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1984; 77(1):77-82. PubMed ID: 6141886.
    Abstract:
    Rainbow trout held in net pens for 4 weeks in three locations contaminated by heavy metals developed elevated levels of hepatic metallothionein but no acclimation to a combination of zinc, copper and cadmium. Toxicity of the mixture of zinc, copper and cadmium in a ratio of 400:20:1 increased with temperature in the range of 6-21 degrees C. Hepatic metallothionein concentrations after 4 weeks of exposure in situ was correlated with the degree of contamination as measured by zinc concentrations (P less than 0.01).
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