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  • Title: The mechanism of the histamine-induced desensitization of guinea-pig ileum.
    Author: Bielkiewicz B, Cook DA.
    Journal: Gen Pharmacol; 1984; 15(1):51-4. PubMed ID: 6141983.
    Abstract:
    Histamine and the selective H1 receptor agonist 2-pyridylethylamine show cross-desensitization when tested in guinea-pig ileum. The H1 receptor blocking agent produces a smaller parallel shift in desensitized tissues when compared with non-desensitized controls. We conclude that desensitization in this system occurs at the receptor level and is reflected by a decreased sensitivity to both agonists and antagonists.
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