These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease.
    Author: Wood PL, Etienne P, Lal S, Nair NP, Finlayson MH, Gauthier S, Palo J, Haltia M, Paetau A, Bird ED.
    Journal: J Neurol Sci; 1983 Dec; 62(1-3):211-7. PubMed ID: 6142096.
    Abstract:
    Assessment of neurochemical markers in the frontal cortex indicates that choline acetyltransferase is significantly decreased in Alzheimer's and Gerstmann-Straussler dementias but not in Pick's dementia. It therefore appears that the cholinergic innervation of the cortex from the basal forebrain is intact in Pick's disease. Cortical somatostatin was decreased only in Alzheimer's disease (AD), indicating that loss of somatostatin is not a constant feature in different forms of dementia. Muscarinic binding sites were unaltered in Pick's disease and Gerstmann-Straussler syndrome but were decreased in a subpopulation of AD patients. These data suggest that in some cases of AD a significant loss of cholinoceptive neurones in the cortex is evident.
    [Abstract] [Full Text] [Related] [New Search]