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  • Title: Synthesis and preliminary characterization of a novel substrate for gamma-glutamyl transferase. A potential anti-hepatoma drug.
    Author: Smith GD, Chakravarty PK, Connors TA, Peters TJ.
    Journal: Biochem Pharmacol; 1984 Feb 15; 33(4):527-9. PubMed ID: 6142715.
    Abstract:
    9he synthesis and chemical characterization of the gamma-glutamyl adduct of phenylenediamine mustard is reported. The activity of this compound, gamma-[N,N-bis(2-chloroethyl)-p-phenylenediamine]-glutamate, as a substrate for gamma-glutamyl transferase is demonstrated and compared with the activity of glutathione. The possible use of this material as a directed anti-hepatoma agent is discussed.
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