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  • Title: Isolation of new lymphotropic retrovirus from two siblings with haemophilia B, one with AIDS.
    Author: Vilmer E, Barre-Sinoussi F, Rouzioux C, Gazengel C, Brun FV, Dauguet C, Fischer A, Manigne P, Chermann JC, Griscelli C.
    Journal: Lancet; 1984 Apr 07; 1(8380):753-7. PubMed ID: 6143082.
    Abstract:
    A human T-lymphotropic retrovirus was isolated from cultured T lymphocytes from two siblings with haemophilia B. Patient 2 was healthy, but patient 1 had acquired immunodeficiency syndrome. The retrovirus differed from human T-cell leukaemia virus (HTLV) but it was similar to the lymphadenopathy-associated retrovirus (LAV) in its morphology and its major core protein (P25). Both patients had antibodies against LAV and patient 1's retrovirus, detected by an enzyme-linked immunosorbent assay or a radioimmunoprecipitation assay. Seroepidemiological data indicated the transmission of this retrovirus by plasma products.
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