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  • Title: Involvement of dynorphin and the kappa opioid receptor in feeding.
    Author: Morley JE, Levine AS.
    Journal: Peptides; 1983; 4(6):797-800. PubMed ID: 6143298.
    Abstract:
    Dynorphin-(1-17) produces a highly specific increase in food ingestion. Similar enhancement of food ingestion is found with dynorphin fragments (1-10), (1-11), (1-13) and (3-13) but not with (1-8) and (1-9). Dynorphin B (rimorphin) also enhances food intake. The highly specific kappa agonist U-50,488 also enhances food intake as do a number of other kappa-opiate receptor agonists. These studies provided further for the role of a highly specific dynorphin-kappa opioid receptor in the modulation of feeding.
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