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  • Title: Effects of 6-methoxytetrahydro-beta-carboline on 5-hydroxytryptamine binding in rat brain.
    Author: Taylor DL, Silverman PB, Ho BT.
    Journal: J Pharm Pharmacol; 1984 Feb; 36(2):125-7. PubMed ID: 6143800.
    Abstract:
    6-MeOTHBC competes for 5-HT binding sites in rat brain in-vitro and in-vivo. The beta-carboline is significantly more active at the type 1 [3H]-5-HT, than the type 2 [3H]spiperone receptors, in-vitro. Following injection, 6-MeOTHBC significantly decreases [3H]-5-HT binding in the cortex. The ineffectiveness on [3H]spiperone binding in-vivo corresponds with the low affinity in-vitro. The effect of 6-MeOTHBC on central 5-HT binding may be a significant aspect of its 5-HT-ergic activity.
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