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  • Title: The hypothalamic paraventricular nucleus: relationship to brain and pituitary pools of vasopressin and oxytocin as compared to dynorphin, beta-endorphin and related opioid peptides in the rat.
    Author: Millan MH, Millan MJ, Herz A.
    Journal: Neuroendocrinology; 1984 Feb; 38(2):108-16. PubMed ID: 6144057.
    Abstract:
    The present study examines the relationship of the hypothalamic paraventricular nucleus (PVN) to discrete brain and pituitary pools of immunoreactive (ir) vasopressin (VP), oxytocin (OT) and particular opioid peptides in the rat. Selective, bilateral destruction of the PVN resulted in a parallel depression in levels of ir-VP, ir-OT, ir-dynorphin (DYN), ir-DYN and ir-alpha-neo-endorphin (alpha-NE) in the neurointermediate lobe of the pituitary, whereas in its anterior counter-part no decrease in the content of any of these peptides was seen. In contrast, the content of ir-beta-endorphin (beta-EP) in the neurointermediate lobe was not significantly altered. Further, a rise in levels of ir-beta-EP in the anterior lobe, together with a fall in these in systemic plasma, was found. In the hypothalamus, in distinction to ir-met-enkephalin (ME), a diminution in the content of ir-VP, ir-OT, ir-DYN, ir-DYN, ir-alpha-NE and, in addition, ir-beta-EP was observed. In the septum, midbrain and medulla/pons, however, a selective depression in levels of ir-VP (and, as measured in the medulla/pons, of ir-OT) was seen: the content of ir-DYN, ir-DYN, ir-alpha-NE, ir-beta-EP and ir-ME was unchanged in these tissues. These data indicate that: (1) the PVN is an important contributor to neurointermediate lobe, but not anterior lobe, pools of ir-VP, ir-OT, ir-DYN, ir-DYN and ir-alpha-NE in contrast to ir-beta-EP.(ABSTRACT TRUNCATED AT 250 WORDS)
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