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  • Title: The effects of diltiazem on Periplaneta americana.
    Author: Jennings KR, Steele RW, Starratt AN.
    Journal: Experientia; 1984 May 15; 40(5):456-8. PubMed ID: 6144568.
    Abstract:
    The effects of the calcium antagonist diltiazem on nerve and muscle in the cockroach Periplaneta americana were examined. Diltiazem was observed to inhibit myogenic and glutamate-induced contractions of the visceral muscle while having either a potentiating, an inhibiting or a biphasic effect against proctolin-induced contractions. Against the isolated nervous system, diltiazem induced an increase in spontaneous discharge activity, followed by nerve block. Injection of diltiazem into cockroaches produced behavioral and toxic effects.
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