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  • Title: Possible prostaglandin-mediated effect of diethylcarbamazine on rat uterine contractility.
    Author: Joseph CA, Dixon PA.
    Journal: J Pharm Pharmacol; 1984 Apr; 36(4):281-2. PubMed ID: 6144785.
    Abstract:
    The effect of diethylcarbamazine pretreatment on uterine contractility was investigated in both pregnant and nonpregnant rats. The pretreatment potentiated the uterine responses to oxytocin and acetylcholine, and enhanced the spontaneous uterine contraction of rats in oestrus or 17-20 days pregnant. This enhanced contraction was antagonized both in-vivo and in-vitro by indomethacin, suggesting the involvement of prostaglandins.
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