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  • Title: MIF-1 (Pro-Leu-Gly-NH2) decreases activity in Siamese fighting fish (Betta splendens).
    Author: Brown MM, Sardenga PB, Olson GA, Delatte SW, Olson RD.
    Journal: Pharmacol Biochem Behav; 1984 Apr; 20(4):629-30. PubMed ID: 6145165.
    Abstract:
    The effects of MIF-1 (Pro-Leu-Gly-NH2) on activity and aggression of male Siamese Fighting Fish ( Betta splendens) were considered. Animals were given intraperitoneal injections of 0.0 or 10.0 mg/kg MIF-1. After a 10-minute delay, they were placed in a 10 gallon aquarium and their activity was monitored for 60 minutes. Although aggressive responses in the presence of suitable opponents were not reliably affected, as significant decrease in general activity was produced. This is compatible with differential effects of MIF-1 across species.
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