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  • Title: Reduced tyrosine hydroxylase activity in nigrostriatal system of sinoaortic-denervated rats.
    Author: Alexander N, Hirata Y, Nagatsu T.
    Journal: Brain Res; 1984 May 14; 299(2):380-2. PubMed ID: 6145496.
    Abstract:
    Tyrosine hydroxylase activity was measured in the caudate nucleus and substantia nigra (pars compacta) of sinoaortic-denervated (SAD) and sham-operated (SO) rats 3 days after operation. The SAD groups had approximately a 50%, statistically significant, reduction of enzyme activity in both regions and also a significant reduction of dopamine in caudate nucleus. These results suggest a probable link between cortico-somatomotor integration and neural input from arterial baroreceptor neural pathways.
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