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  • Title: [Mechanisms of the phenazepam oxidation reactions in cell membranes].
    Author: Golovenko NIa, Meteshkin IuV.
    Journal: Farmakol Toksikol; 1984; 47(3):97-101. PubMed ID: 6145623.
    Abstract:
    During phenazepam oxidation by rat, mouse and rabbit liver microsomes, the maximal amount of products was formed if NADP-H was used as electron donor. Addition of equimolar concentration of NAD-H did not stimulate phenazepam oxidation. The monooxygenase inhibitor, SKF-525A, reduced the rate of phenazepam oxidation depending on the type of experimental animals. The mechanisms of enzymatic formation from phenazepam of 3-hydroxymetabolite, quinazoline and aromatic hydroxylation products are discussed.
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