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  • Title: [Analysis of factors limiting the applications of binomial statistics in studies of mediator secretion at neuromuscular synapses].
    Author: Zefirov AL, Stolov EL.
    Journal: Neirofiziologiia; 1984; 16(2):182-9. PubMed ID: 6146099.
    Abstract:
    Binomial parameters of transmitter secretion were calculated on the basis of synaptic potential analyses at frog sartorius muscle. In some synapses negative values of parameter of the p were found. These negative values often occurred at low concentrations of Ca2+ ions and small amplitude of miniature end plate potentials. The obtained data were interpreted in terms of a model which presupposes the heterogeneity of the quantum transmitter release at different sites. A computer imitation of transmitter secretion showed that the appearance of the negative p parameter values and erroneous n estimations in the experiment are related with the shape of the distribution of quantum transmitter release probability and the amplitude of miniature end plate potentials.
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