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  • Title: [Role of transmembrane ion currents in the mechanism of action of beta-adrenoblockers].
    Author: Porotikov VI, Cherenshchikova EA, Filippov AK, Mashkovskiĭ MD, Iuzhakov SD.
    Journal: Biull Eksp Biol Med; 1984 Jun; 97(6):677-9. PubMed ID: 6146358.
    Abstract:
    The effects of propranolol, oxprenolol, pindolol, labetalol, and atenolol on the isoproterenol-stimulated slow calcium current as well as on spontaneous slow calcium and fast sodium currents were studied in frog trabeculae by the double sucrose bridge technique. Administration of beta-adrenoblockers in low doses (10(-7)-10(-6)M) antagonized the stimulatory effect of isoproterenol on the slow calcium current (pindolol greater than oxprenolol greater than or equal to propranolol = labetalol greater than atenolol). When administered in high doses (2 X 10(-6)-10(-4)M) the beta-adrenoblockers reduced the slow calcium current. Meanwhile, some of them (propranolol, oxprenolol, labetalol) suppressed the fast sodium current.
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