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  • Title: Regulation of rat renal (Na+ + K+)-adenosine triphosphatase activity by triiodothyronine and corticosterone.
    Author: Klein LE, Hsiao P, Bartolomei M, Lo CS.
    Journal: Endocrinology; 1984 Sep; 115(3):1038-42. PubMed ID: 6146514.
    Abstract:
    The present study concerns the effects of corticosterone and T3 on renal cortical and outer medullary NaK-ATPase activities in the rat. The results show that corticosterone increases cortical and outer medullary NaK-ATPase activities when administered as either a single or multiple doses. Corticosterone and T3 are known to enhance NaK-ATPase activity. We investigate the possibility of interaction between the effects of corticosterone and T3 on renal NaK-ATPase activity. Our studies indicate that corticosterone and T3 regulate renal cortical NaK-ATPase activity via parallel independent pathways, and that corticosterone appears to regulate medullary NaK-ATPase activity without participation by thyroid hormone.
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