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  • Title: Ranitidine 150 mg twice daily vs 300 mg nightly in treatment of duodenal ulcers.
    Author: Ireland A, Colin-Jones DG, Gear P, Golding PL, Ramage JK, Williams JG, Leicester RJ, Smith CL, Ross G, Bamforth J.
    Journal: Lancet; 1984 Aug 04; 2(8397):274-6. PubMed ID: 6146821.
    Abstract:
    102 patients with endoscopically proven duodenal ulcers were randomly allocated to treatment with ranitidine either 150 mg twice a day or 300 mg every evening for 4 weeks in a prospective double-blind study. The two groups were similar. 48/57 (84%) healed on ranitidine 150 mg twice daily and 43/45 (96%) healed on 300 mg every evening (p = 0.9)--that is, ranitidine 300 mg as a single night time dose is as effective as 150 mg twice daily. The results also indicate the importance of overnight gastric acidity in the pathogenesis of duodenal ulcers.
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