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  • Title: Corticotrophin releasing factor: effects on circulating gut and pancreatic peptides in man.
    Author: Lytras N, Grossman A, Rees LH, Schally AV, Bloom SR, Besser GM.
    Journal: Clin Endocrinol (Oxf); 1984 Jun; 20(6):725-9. PubMed ID: 6147213.
    Abstract:
    As a CRF-like peptide has been isolated from human gut, we investigated the effect of synthetic CRF-41 100 micrograms on gut and pancreatic peptides in six normal subjects. There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen. In addition, there was no change in circulating met-enkephalin. We conclude that the rise in pancreatic polypeptide seen after CRF administration may suggest a role for a CRF-like peptide in the control of pancreatic function.
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