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  • Title: Regulation of proximal bicarbonate reabsorption.
    Author: Cogan MG, Alpern RJ.
    Journal: Am J Physiol; 1984 Sep; 247(3 Pt 2):F387-95. PubMed ID: 6148019.
    Abstract:
    Under free-flow conditions, alterations in acid-base and extracellular volume status affect absolute proximal bicarbonate reabsorption. Microperfusion studies have characterized the individual determinants of the active and passive components of proximal acidification. These determinants include luminal bicarbonate concentration, luminal flow rate, peritubular bicarbonate concentration, PCO2, extracellular volume status, and solute-solvent interactions. When these individual determinants are integrated into a computer-simulated model of absolute proximal bicarbonate reabsorption, the results agree well with the in vivo free-flow data.
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