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  • Title: Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation.
    Author: Lakoski JM, Gallager DW, Aghajanian GK.
    Journal: Eur J Pharmacol; 1984 Aug 03; 103(1-2):153-6. PubMed ID: 6148254.
    Abstract:
    Microiontophoretic application of the histamine H2-receptor antagonist cimetidine selectively attenuated the histamine-induced, but not the gamma-aminobutyric acid (GABA)-induced, depression of serotoninergic cells recorded in the dorsal raphe nucleus of the rat. These data support the view that an H2-receptor mediates the effects of histamine on these serotoninergic neurons. We also now ascribe a previous report of GABA-like properties of cimetidine and metiamide to an impurity in the lots of these compounds used originally.
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