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  • Title: Kappa-opioid diuretic effects of tifluadom, a benzodiazepine opioid agonist.
    Author: Leander JD.
    Journal: J Pharm Pharmacol; 1984 Aug; 36(8):555-6. PubMed ID: 6148404.
    Abstract:
    Tifluadom produced a dose-related (0.08-5 mg kg-1) diuresis in normally hydrated rats. This diuretic effect was antagonized by kappa-antagonist doses of naloxone and blocked by morphine administration. This is further in-vivo evidence that tifluadom is a fairly specific kappa-opioid agonist.
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