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  • Title: Evidence for the existence of histamine H1- and H2-receptors on astrocytes of cultured rat central nervous system.
    Author: Hösli L, Hösli E, Schneider U, Wiget W.
    Journal: Neurosci Lett; 1984 Aug 10; 48(3):287-91. PubMed ID: 6148726.
    Abstract:
    By means of intracellular microelectrodes we have studied the action of histamine H1- and H2-agonists and -antagonists on the membrane potential of astrocytes in cultured rat brainstem and spinal cord. Histamine at high concentrations (10(-4) and 10(-5) M) mainly depolarized the glial membrane, whereas at low concentration (10(-6) M) it usually caused hyperpolarizations. The histamine-induced depolarizations were reversibly blocked by the H1-antagonist pyrilamine, whereas the H2-antagonist cimetidine antagonized the hyperpolarizations. The H1-agonist thiazolethylamine mainly produced depolarizations while impromidine, a H2-agonist, predominantly caused hyperpolarizations. Our findings, together with autoradiographic binding studies, provide strong evidence for the existence of histamine H1- and H2-receptors on astrocytes.
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