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  • Title: Effect of steroidal sex hormones on the sex-related differences in the hepatic activities of gamma-glutamyltranspeptidase, glutathione S-transferase and glutathione peroxidase in rats.
    Author: Igarashi T, Satoh T, Ono S, Iwashita K, Hosokawa M, Ueno K, Kitagawa H.
    Journal: Res Commun Chem Pathol Pharmacol; 1984 Aug; 45(2):225-32. PubMed ID: 6148776.
    Abstract:
    The activities of gamma-glutamyltranspeptidase (gamma-GTP) and glutathione peroxidase (GSH-Px) were higher in female than in male rat liver. Glutathione S-transferase (GST) activities were conversely higher in males than females. Estradiol administration to castrated rats enhanced the gamma-GTP activity. Castration produced a significant increase in GSH-Px activities which was reduced to the control level by subsequent testosterone treatment. Ovariectomized rats had markedly increased the GST activity. These results suggest that GSH-related enzymes studied here may be subject to modulation by androgenic and estrogenic influences.
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