These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Sensitization of mice to rickettsial toxin by Coxiella burnetii.
    Author: Kazár J, Schramek S.
    Journal: Acta Virol; 1984 Jul; 28(4):309-16. PubMed ID: 6148856.
    Abstract:
    Intraperitoneal (ip.) inoculation with live or killed Coxiella burnetii (C.b.) rendered mice more sensitive to intravenous (iv.) administration of a toxic live suspension of Rickettsia typhi. Sensitization of mice by live and killed C.b. was time-and dose-dependent. Killed phase I and phase II C.b. cells possessed a similar degree of sensitization, which was increased slightly by their preincubation with corresponding immune sera. Lipopolysaccharide (LPS)-protein complex extracted from phase I C.b. cells exerted lower sensitization than whole phase I C.b. cells, and chloroform-methanol (CM) treatment of phase I C.b. cells reduced markedly their sensitizing effect. No toxic effect was observed either in C.b.-inoculated or in control mice upon i.v. administration of a heated R. typhi suspension. Specificity of rickettsial toxicity was demonstrated by its distinct reduction both in control and C.b.-inoculated mice after preincubation of R. typhi suspension with immune anti-R. typhi mouse serum.
    [Abstract] [Full Text] [Related] [New Search]