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  • Title: Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.
    Author: Nelkin BD, Rosenfeld KI, de Bustros A, Leong SS, Roos BA, Baylin SB.
    Journal: Biochem Biophys Res Commun; 1984 Sep 17; 123(2):648-55. PubMed ID: 6148938.
    Abstract:
    Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.
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