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  • Title: Episodic growth hormone secretion in the domestic fowl (Gallus domesticus): alpha adrenergic regulation.
    Author: Buonomo FC, Lauterio TJ, Scanes CG.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1984; 78(2):409-13. PubMed ID: 6149089.
    Abstract:
    In animals the secretion of GH is characterized by a series of spontaneous peaks. The situation in avian species, however, is unknown. The present study examines this in the domestic fowl. Blood samples were obtained via a remote catheter at 5-min intervals from young male chickens. An episodic pattern of GH secretion was observed having an interpulse interval (frequency) of approximately 1 h. Episodic GH secretion was altered by peripheral administration of drugs which influence adrenergic function. Spontaneous GH peaks were not observed following the administration of (1) bis-(4-methyl-1-homopiperazinyl-thiocarbonyl) disulfide (FLA63) or diethyldithiocarbamate (DDC) (which blocks norepinephrine (NE) and epinephrine (E) synthesis by inhibiting dopamine-beta-hydroxylase), (2) phenoxybenzamine (an alpha 1-adrenergic antagonist) and (3) clonidine (an alpha 2-adrenergic agonist). Neither alpha-methyl-p-tyrosine, which blocks dopamine (DA), NE and E synthesis, nor yohimbine, a predominantly alpha 2-antagonist could completely suppress episodic GH secretion. These data support a role for NE/E, acting via alpha adrenergic receptors, in the control of epidosic GH secretion in the domestic fowl.
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