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  • Title: Malacoplakia associated with vesicoureteral reflux and selective immunoglobulin A deficiency.
    Author: Witherington R, Branan WJ, Wray BB, Best GK.
    Journal: J Urol; 1984 Nov; 132(5):975-7. PubMed ID: 6149321.
    Abstract:
    A case of malacoplakia involving the lower urinary tract of a young black boy, with associated bilateral vesicoureteral reflux, hydronephrosis and selective immunoglobulin A deficiency is reported. Reflux was caused by the malacoplakia. Reflux and hydronephrosis persisted despite elimination of bacterial infection and malacoplakia by drug therapy. These abnormalities were corrected by a conventional antireflux operation. Malacoplakia appears to be related to immunologic incompetence and diminished levels of intracellular cyclic 3',5' guanine monophosphate. Cholinergic agonists reverse or prevent the pathological changes of malacoplakia.
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