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  • Title: Ion channel block in rat diaphragm by the venom of the digger wasp Philanthus triangulum.
    Author: van Wilgenburg H, Piek T, Mantel P.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1984; 79(1):205-11. PubMed ID: 6149868.
    Abstract:
    In the rat phrenic nerve-diaphragm preparation the twitch tension and tetanic contractions, already reduced by d-tubocurarine, succinylchloride or neostigmine, are further reduced by the venom of the digger wasp Philanthus triangulum F. The venom reduces the temperature- and voltage-sensitivity of the acetylcholine-receptor-activated ion channels, at the motor end-plate, and shortens the decay time of the miniature end-plate currents, analogous to a block described for the purified toxin, delta-PTX, on insect glutamate-activated channels. Preliminary results show that delta-PTX has an effect similar to that of the total venom on the decay phase of miniature end-plate currents.
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