These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: The action and interaction of beta-phenethylamines and imidazolines on prejunctional alpha 2-adrenoceptors of guinea-pig ileum in the presence of the non-competitive antagonist benextramine.
    Author: Mottram DR, Thakar Y.
    Journal: J Pharm Pharmacol; 1984 Oct; 36(10):668-72. PubMed ID: 6150083.
    Abstract:
    The effects of benextramine, a selective non-competitive, irreversible antagonist of alpha-adrenoceptors, against alpha 2-adrenoceptor agonists has been investigated in isolated field-stimulated guinea-pig ileum. Benextramine was equipotent against the imidazoline, clonidine and the thiazoloazepine B-HT920, however, higher concentrations of benextramine were required for an equivalent non-competitive antagonism of the beta-phenethylamine, alpha-methylnoradrenaline. Using benextramine to differentially block the agonist effects of clonidine but not alpha-methylnoradrenaline it was shown that clonidine can competitively antagonize the effects of alpha-methylnoradrenaline. From these and previous results on the differential effects of imidazoline-like and beta-phenethylamine-like drugs on alpha 2-adrenoceptors, it is proposed that two distinct populations of these receptors exist.
    [Abstract] [Full Text] [Related] [New Search]