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  • Title: 4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer.
    Author: Coombes RC, Goss P, Dowsett M, Gazet JC, Brodie A.
    Journal: Lancet; 1984 Dec 01; 2(8414):1237-9. PubMed ID: 6150277.
    Abstract:
    4-hydroxyandrostenedione, a potent inhibitor of the aromatase (oestrogen synthetase) system, was given to 11 patients with metastatic breast cancer. After a single 500 mg intramuscular injection a sustained reduction of serum oestradiol was observed for at least 1 week in all patients in whom the steroid was measured. 4 patients responded to treatment for periods of up to 4 months, and healing of bone metastases and reduction in size of soft-tissue metastases was evident. The only side-effects were pain at the injection site and hot flushes. 4-hydroxyandrostenedione is a new and specific aromatase inhibitor which shows promise in the treatment of patients with metastatic breast cancer.
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