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  • Title: Acetoacetate utilization by human placental mitochondria.
    Author: Zołnierowicz S, Scisłowski PW, Swierczyński J, Zelewski L.
    Journal: Placenta; 1984; 5(3):271-6. PubMed ID: 6150478.
    Abstract:
    It has been shown that mitochondria from human placenta incubated in the presence of 2-oxoglutarate or its precursors utilize acetoacetate at the rate about I nmol/min/mg protein. Utilization of acetoacetate is completely inhibited by arsenite. Mitochondria from human placental tissue show activity of 3-oxoacid-CoA transferase and acetoacetyl-CoA thiolase. It is proposed that acetoacetate utilization by placental mitochondria proceeds via the conversion to acetoacetyl-CoA catalysed by 3-oxoacid-CoA transferase, and then to acetyl-CoA, catalysed by acetoacetyl-CoA thiolase.
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