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  • Title: Treatment of negative schizophrenic symptoms with alprazolam: a preliminary open-label study.
    Author: Csernansky JG, Lombrozo L, Gulevich GD, Hollister LE.
    Journal: J Clin Psychopharmacol; 1984 Dec; 4(6):349-52. PubMed ID: 6150950.
    Abstract:
    Eight schizophrenic patients received alprazolam in an open-label protocol. A partial reversal of negative symptoms was noted in six of the eight patients. Also, all eight experienced a decrease in anxiety. Alprazolam in doses of 5 to 7 mg/day yielded steady state plasma levels of 6 to 64 ng/ml. As the drug was well tolerated at these doses and as negative symptoms of schizophrenia are difficult to treat, a double-blind, controlled trial of alprazolam is underway to test more rigorously these preliminary results.
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