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  • Title: Characterization of mutations that lie in the promoter-regulatory region for glnA, the structural gene encoding glutamine synthetase.
    Author: McCarter L, Krajewska-Grynkiewicz K, Trinh D, Wei G, Kustu S.
    Journal: Mol Gen Genet; 1984; 197(1):150-60. PubMed ID: 6151113.
    Abstract:
    In enteric bacteria products of nitrogen regulatory genes ntrA, ntrB and ntrC are known to regulate transcription both positively and negatively at glnA, the structural gene encoding glutamine synthetase [L-glutamate:ammonia-ligase (ADP-forming), EC 6.3.1.2]. We have characterized two types of cis-acting mutations in the glnA promoter-regulatory region. One type, which we have called promoter Up [glnAp (Up)], elevates transcription of glnA to high levels without need for ntr-mediated activation but leaves expression sensitive to ntr-mediated repression. The other type renders glnA transcription insensitive to repression but leaves it normally responsive to activation. Properties of the two types of promoter-regulatory mutations suggest that sites for ntr-mediated activation of glnA transcription are functionally distinct from sites for ntr-mediated repression.
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