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  • Title: Behavioral suppression using intracranial reward and punishment: effects of benzodiazepines.
    Author: Moriyama M, Ichimaru Y, Gomita Y.
    Journal: Pharmacol Biochem Behav; 1984 Nov; 21(5):773-8. PubMed ID: 6151197.
    Abstract:
    Rats were chronically implanted with electrodes aimed at the lateral hypothalamus (LH) and the dorsal central gray (DCG) and trained to press a lever that delivered rewarding stimulation of the LH and punishing stimulation of the DCG. In this situation, both diazepam (5-20 mg/kg, PO) and bromazepam (2-10 mg/kg, PO) caused a marked dose-dependent increase of the lever pressing response in the punished period. In addition, the facilitation of lever pressing in unpunished period was also seen in diazepam (5 and 10 mg/kg). These results show that behavioral suppression on lever pressing maintained self-stimulation reward is inducible following DCG stimulation, and that benzodiazepines exhibit an anti-behavioral suppression effect in this situation.
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