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  • Title: A double-blind study of the effect of trimipramine in patients with the irritable bowel syndrome.
    Author: Myren J, Løvland B, Larssen SE, Larsen S.
    Journal: Scand J Gastroenterol; 1984 Sep; 19(6):835-43. PubMed ID: 6151243.
    Abstract:
    The study was performed in 428 patients, of whom 216 were women. The median age was 36.5 (16-75) years and the median weight 67 (42-118) kg. The complaints were registered on a 10-cm-long linear analogue scale by the patients and the physicians. The patients were given coded identical-appearing tablets of placebo and different doses of trimipramine (Surmontil, Rhône-Poulenc) and randomized into groups A-E. During the 6 weeks of treatment the grades of complaints were reduced to about the half of pretreatment levels. The groups treated with trimipramine (groups A-D) felt significantly more improved than the group receiving placebo (group E). The side effect of tiredness was somewhat more pronounced 1-2 weeks after start with 50 mg trimipramine in the evening than in the groups receiving placebo and lower dose schedules of trimipramine.
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