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  • Title: Hypotensive action and alpha-adrenolytic properties of a new dopaminergic agonist, CU 32-085, in the rat.
    Author: Morales-Olivas FJ, Palop V, Rubio E, Esplugues J.
    Journal: Arch Int Pharmacodyn Ther; 1984 Nov; 272(1):71-8. PubMed ID: 6151381.
    Abstract:
    The effect of an 8-alpha-amino-ergoline-derivative, CU 32-085, recently characterized as a dopamine agonist, was studied on blood pressure and heart rate in normotensive anesthetized rats. The effects of CU 32-085 and bromocriptine on dose-response curves to sympathomimetic agents (adrenaline, noradrenaline, methoxamine and clonidine), intravenously administered, were also studied. CU 32-085 slowed heart rate and lowered blood pressure. The hypotensive effect was antagonized by pretreatment with sulpiride. CU 32-085 and bromocriptine reduced the pressor effect of adrenaline, noradrenaline and methoxamine and the hypotensive action of clonidine. These results suggest that the hypotensive action of CU 32-085, like bromocriptine, is mainly due to an action on dopaminergic receptors. In addition, the data obtained with sympathomimetic agents suggest that CU 32-085 is a compound with mixed alpha 1 and alpha 2 antagonist properties, similar to bromocriptine.
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