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Title: Thiazolidine-2-carboxylate derivatives formed from glyoxylate and L-cysteine or L-cysteinylglycine as possible physiological substrates for D-aspartate oxidase. Author: Burns CL, Main DE, Buckthal DJ, Hamilton GA. Journal: Biochem Biophys Res Commun; 1984 Dec 28; 125(3):1039-45. PubMed ID: 6151397. Abstract: Adducts of glyoxylate with L-cysteine or L-cysteinylglycine were found to be excellent substrates at low concentrations for beef kidney D-aspartate oxidase. Evidence is presented that cis-thiazolidine-2,4-dicarboxylate and its glycine amide are the actual substrates, and that both are converted in the enzymic reaction to 4-substituted thiazoline-2-carboxylates. The results imply that these thiazolidine derivatives are the likely physiological reactants for mammalian D-aspartate oxidase.[Abstract] [Full Text] [Related] [New Search]