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  • Title: Tyr-MIF-1 acts as an opiate antagonist in the tail-flick test.
    Author: Kastin AJ, Stephens E, Ehrensing RH, Fischman AJ.
    Journal: Pharmacol Biochem Behav; 1984 Dec; 21(6):937-41. PubMed ID: 6151669.
    Abstract:
    The naturally occurring brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) was tested for its ability to block and reverse the actions of morphine in the tail-flick test. Injected peripherally either 10 minutes before or after morphine, Tyr-MIF-1, like MIF-1, was found to significantly reduce the antinociceptive actions of morphine on thermal pain. The results indicate that Tyr-MIF-1 may act, in part, as an endogenous opiate antagonist.
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