These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Phosphatidylinositol 4,5-biphosphate stimulates parotid endoplasmic reticulum (Ca2+ + Mg2+)-ATP'ase.
    Author: Thiyagarajah P, Lim SC.
    Journal: Biochem Int; 1984 Nov; 9(5):625-30. PubMed ID: 6151839.
    Abstract:
    The effect of various phospholipids on the (Ca2+ + Mg2+)-ATP'ase of rat parotid endoplasmic reticulum was investigated. At a concentration of 20 micrograms/ml, phosphatidylinositol 4,5-biphosphate stimulated the Ca2+-activated ATP'ase by 69%. None of the other phospholipids tested or 10 microM inositol 1,4,5-triphosphate had any significant effect on the ATP'ase. Stimulation by phosphatidylinositol 4,5-biphosphate was concentration dependent and half maximal stimulation required 8 micrograms/ml of the phospholipid. The results suggest that changes in the cellular concentration of phosphatidylinositol 4,5-biphosphate may be of importance in regulating Ca2+ transport by the endoplasmic reticulum.
    [Abstract] [Full Text] [Related] [New Search]