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  • Title: Purification of herpes simplex virus-specified major DNA-binding proteins and detection of antibodies to them in human and rabbit sera.
    Author: Lehtinen M, Lehtinen T, Koivisto V, Paavonen J, Leinikki P.
    Journal: Acta Virol; 1984 Nov; 28(6):449-56. PubMed ID: 6152122.
    Abstract:
    We purified herpes simplex virus type 1 and 2-specified nonstructural DNA-binding proteins (ICP8 and ICSP 11/12, respectively) from infected Vero cells and applied them in ELISA test to analyse human and rabbit sera. Only a weak immune response to the ICP8 and ICSP 11/12 could be demonstrated following experimental HSV-1 or HSV-2 infections of rabbits. Low levels of ICSP8 antibodies were found also in acute HSV infections of man.
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