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  • Title: Pilot clinical trial with a new beta 2-sympathomimetic bronchodilator, mabuterol.
    Author: Ulmer WT, Scholz HJ, Baines A.
    Journal: Arzneimittelforschung; 1984; 34(11A):1697-8. PubMed ID: 6152165.
    Abstract:
    An open pilot study was performed on 10 patients with chronic, reversible, obstructive lung disease and known good response to beta 2-bronchodilators. The effects of 40, 60 and 80 micrograms 1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) given orally and of 0.4 mg fenoterol (aerosol) were measured on airway resistance, thoracic gas volume, pulse rate and blood pressure. Side effects, ECG and laboratory values were recorded. Mabuterol was found to have a good, clinically useful, bronchodilating effect and to possess excellent tolerability at doses of 40-60 micrograms.
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