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  • Title: [Asymmetrical synthesis of (R)(-) and (S)(+)-etilefrine by enantioselective hydrogenation and the effects of enantiomers in an animal experiment].
    Author: Knorr H, Reichl R, Traunecker W, Knappen F, Brandt K.
    Journal: Arzneimittelforschung; 1984; 34(12):1709-13. PubMed ID: 6152167.
    Abstract:
    The enantiomers of etilefrine (Effortil) were produced by enantioselective hydrogenation. The optical purity was determined by conversion with (+)-[(R)-tetrahydrofurfuryl-(1S)-camphor-10-sulfonate] to N-[(R)-tetrahydrofurfuryl]-etilefrine and subsequent separation of the diastereomers by HPLC. An animal experiment showed that the (R)(-)-enantiomer is more effective.
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