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  • Title: [Pharmacokinetics and pharmacodynamics of vecuronium in children].
    Author: Steinbereithner K, Fitzal S, Schwarz S, Gilly H, Semsroth M, Weindlmayr-Goettel M.
    Journal: Cah Anesthesiol; 1984; 32(1):5-10. PubMed ID: 6152193.
    Abstract:
    Pharmacodynamics of vecuronium have been studied in children 1 to 10 years old. Doses from 0.015 to 0.1 mg/kg were given and the effects measured mechanically and by electromyography. For 0.1 mg/kg the pharmacokinetics were established. A smaller distribution volume and higher plasma clearance in children as compared to adults have been found, while the dose-effect ratio is the same. The action of vecuronium is shorter in children than in adults.
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