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  • Title: The antihypertensive effect of taurine in DOCA-salt rats.
    Author: Fujita T, Sato Y.
    Journal: J Hypertens Suppl; 1984 Dec; 2(3):S563-5. PubMed ID: 6152784.
    Abstract:
    We studied the role of the sympathetic nervous system in the antihypertensive actions of taurine in DOCA (deoxycorticosterone acetate)-salt hypertensive rats. Supplementation with 1% taurine could moderate the development of the DOCA-salt hypertension. Norepinephrine turnover was measured from the rate of decline of tissue norepinephrine concentration after the administration of alpha-methyl-p-tyrosine. Cardiac and splenic norepinephrine turnover was markedly accelerated in the DOCA-salt rats compared with the vehicle-treated control rats, but the 1% taurine supplements could normalize this. These results suggest that the normalization of the increased sympathetic activity may be involved in the antihypertensive actions of taurine in DOCA-salt hypertensive rats.
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