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  • Title: Polyclonal B lymphocyte activation during Trypanosoma cruzi infection.
    Author: Ortiz-Ortiz L, Parks DE, Rodriguez M, Weigle WO.
    Journal: J Immunol; 1980 Jan; 124(1):121-6. PubMed ID: 6153088.
    Abstract:
    Infection of A/J mice with Trypanosoma cruzi results in the polyclonal activation of B lymphocytes in vivo as assessed by the spontaneous plaque-forming cell (PFC) response to trinitrophenyl and to goat, equine, and sheep erythrocytes. The peak response to these antigens is found at 5 to 6 days of infection. Additionally, a polyclonal response to syngeneic erythrocytes can be detected in infected mice by using aged but not fresh indicator cells. Polyclonally stimulated PFC to human gamma-PFC found late in infection during a period of marked splenomegaly and parasitemia. This trypanosoma-induced polyclonal B cell activation may well be responsible for the abnormalities in immunoglobulin synthesis and secretion that have been reported to occur during human infection with T. cruzi.
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