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  • Title: Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein.
    Author: Theoharides TC, Sieghart W, Greengard P, Douglas WW.
    Journal: Science; 1980 Jan 04; 207(4426):80-2. PubMed ID: 6153130.
    Abstract:
    Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.
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