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  • Title: Circumscribed scleroderma with immunologic evidence of systemic lupus erythematosus.
    Author: Mitchell AJ, Rusin LJ, Diaz LA.
    Journal: Arch Dermatol; 1980 Jan; 116(1):69-73. PubMed ID: 6153258.
    Abstract:
    An 8-year-old girl initially manifested clinical and histopathologic findings of circumscribed scleroderma. She had both linear and plaque lesions. Although she was free of constitutional symptoms, laboratory evaluation revealed substantial evidence of systemic lupus erythematosus (SLE). This included a positive anti-nuclear antibody test (rim pattern), positive LE cell preparation test, elevated anti-double-stranded DNA activity, positive lupus band test (IgM and C3) in involved and uninvolved skin, and renal biopsy findings consistent with SLE. Sclerodermatous change as an initial sign of SLE is rare. We review previous reports of an association of circumscribed scleroderma, especially the linear form, with serologic evidence of systemic autoimmune disease.
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