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  • Title: Sleep-waking cycle in microencephalic rats induced by prenatal methylazoxymethanol application.
    Author: Kiyono S, Seo M, Shibagaki M.
    Journal: Electroencephalogr Clin Neurophysiol; 1980 Jan; 48(1):73-9. PubMed ID: 6153325.
    Abstract:
    Sleep-wakefulness cycle of adult microencephalic rats due to prenatal administration of methylazoxymethanol (MAM) acetate at the dose of 20 mg/kg on the 15th day of gestation showed no difference from the normal control group, whereas at the dose of 25 mg/kg, %PS and PS/TS decreased significantly. MAM-induced microencephalic rats revealed a significant increase of spindle bursts during PS, suggesting that their PS is less deep than that of the controls.
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