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  • Title: Distribution of substance P in the rat gastrointestinal tract--lack of effect of capsaicin pretreatment.
    Author: Holzer P, Gamse R, Lembeck F.
    Journal: Eur J Pharmacol; 1980 Feb 08; 61(3):303-7. PubMed ID: 6153986.
    Abstract:
    A new method for extraction of immunoreactive substance P (I-SP) from rat intestine including pulverization of tissue frozen in liquid nitrogen and extraction with acid acetone is described. Using this method, amounts of I-SP in the rat intestine were found to be higher than previously reported. The highest concentrations of I-SP were found in the small intestine. Capsaicin pretreatment of newborn or adult rats had no effect on intestinal I-SP concentrations indicating that intrinsic SP neurones are capsaicin-insensitive.
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